Research My major research interest is in immune responses to pathogens and their products. The focus is currently on mucosal immune responses in pigs infected with Porcine Reproductive and Respiratory Syndrome (PRRS) virus. PRRS virus causes a range of clinical signs in pigs, depending on the age of the animal. Lung (alveolar) macrophages are a major target for PRRS virus infection and replication, and in vitro studies are focused on interaction between PRRS virus and the porcine alveolar macrophage. I also retain an interest in evaluating the mucosal immune response to Cryptosporidium parvum, a zoonotic protozoan that causes diarrheal disease in humans and neonatal calves. Selected publications Wang, H-F, Swain JB, Besser TE, Jasmer D, and Wyatt, CR. 2003. Detection of antibodies to a recombinant Cryptosporidium parvum p23 in serum and feces from neonatal calves. J. Parasitol. 89:918-923. Wyatt, CR and McDonald V. Innate and T cell-mediated immune responses in cryptosporidiosis. IN: World Class Parasites: The Pathogenic Gut Protozoa. C. Sterling and R. Adam, eds., Kluwer Academic Publishers, Boston. 2004, pp. 91-102. Wyatt, CR, Lindahl S, Austin K, Kapil S, and Branch J. 2005. Response of T lymphocytes from previously infected calves to recombinant Cryptosporidium parvum p23 vaccine antigen. J. Parasitol. 91:1239-1242. Green JL, Andrews GA, and Wyatt, CR. 2005. Phenotypic differences within the AB blood type of the feline AB blood group system. Comp. Clin. Pathol. 14:138-145. Rogers DP, Wyatt, CR, Walz PH, Drouillard JS, and Mosier DA. 2006. Bovine alveolar macrophage neurokinin-1 and response to substance P. Vet. Immunol. Immunopathol. 112:290-295. Moore SM, Wilkerson MJ, Briggs DJ, Wyatt, CR, and Davis RD. 2006. Detection of cellular immunity to rabies antigens in human vaccines. J. Clin Immunol. 26:5323-545. Wyatt, CR, Brackett, EJ, Perryman, LE, and Davis, WC. 1996. Identification of T lymphocyte subsets that populate calf ileal mucosa after birth. Vet. Immunol. Immunopathol. 52:91-103. Johnson, WC, Cluff, CW, Goff, WL, and Wyatt, CR. 1996. Reactive oxygen and nitrogen intermediates and products from polyamine degradation are babesiacidal in vitro. Ann. N.Y. Acad. Sci. 791:136-147. Goff, WL, Johnson, WC, Wyatt, CR, and Cluff, CW. 1996. Assessment of bovine mononuclear phagocytes and neutrophils for induced L-arginine-dependent nitric oxide production. Vet. Immunol. Immunopathol. 55:45-62. Wyatt, CR, Brackett, EJ, Perryman, LE, Rice-Ficht, AC, Brown, WC, and O'Rourke, KI. 1997. Activation of intestinal intraepithelial T lymphocytes in calves infected with Cryptosporidium parvum Inf. Immun. 65:185-190. Goff, WL, O'Rourke, KI, Johnson, WC, Lacy, PA, Davis, WC, and Wyatt, CR. 1998. Bovine mononuclear phagocyte iNOS and cytokine mRNA expression in vitro: evidence for IL-10 regulation. J. Interferon and Cytokine Res. 18:139-149. Wyatt, CR, Barrett, WJ, Brackett, EJ, Davis, WC, and Besser, TE. 1999. Phenotypic comparison of ileal intraepithelial lymphocyte populations of suckling and weaned calves. Vet. Immunol. Immunopathol. 67:213-222. Wyatt, CR, Brackett, EJ, and Barrett, WJ. 1999. Accumulation of mucosal T lymphocytes around epithelial cells after in vitro infection with Cryptosporidium parvum. J. Parasitol. 85:765-768. Wyatt, CR, Brackett, EJ, Mason, PH, Savidge, J, and Perryman, LE. 2000. Excretion patterns of mucosally delivered antibodies to p23 in Cryptosporidium parvum infected calves. Vet. Immunol. Immunopathol. 76:309-317. Wyatt, CR. 2000. Cryptosporidium parvum and mucosal immunity in neonatal cattle. An. Health Res. Rev. 1:25-34. Wyatt, CR, and Perryman, LE. 2000. Detection of mucosally delivered antibody to Cryptosporidium parvum p23 in infected calves. Ann. N.Y. Acad. Sci. 916:378-387. Wyatt, CR, Brackett, EJ, and Savidge, J. 2001. Evidence for the emergence of a Type-1-like immune response in intestinal mucosa of calves recovering from cryptosporidiosis. J. Parasitol. 87:90-95. Wyatt, CR, Barrett, WJ, Brackett, EJ, Schaefer, DA, and Riggs, MW. 2002. Association of IL-10 expression by mucosal lymphocytes with increased expression of Cryptosporidium parvum epitopes in infected epithelium. J. Parasitol. 88:281-286. Swist SL, Wilkerson MJ,
Wyatt, CR,
Broce AB, and Kanost MR. 2002. Modulation of bovine lymphocyte response
by salivary gland extracts of the stable fly,
Stomoxys calcitrans (Diptera:
Muscidae). J. Med. Entomol. 39:900-907. |
