K-State

College of Veterinary Medicine

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Research Interests:

My research has focused on clarification of the involvement of angiotensin II and its signaling in chemical carcinogen-induced tumorigenesis in the colon and lung. Currently, the following studies are in progress: a) determination of whether pharmacological and/or genetic intervention (blockage of angiotensin II receptor function) attenuate chemical carcinogen-induced tumorigenesis in the lung and colon; b) investigation of whether a positive or negative correlation exists between angiotensin II receptor gene polymorphisms and human lung cancer in lung cancer patients and corresponding normal control subjects. In addition, determination of the therapeutic potential of genetically engineered umbilical cord matrix-derived stem cells in lung cancer is an ongoing collaborative research project with the KSU stem cell research group (Drs. Troyer and Weiss).

Selected Publications:

Hunley, T.E., Tamura, M., Stoneking, B., Nishimura, H., Inagami T., and Kon, V.: The angiotensin receptor type 2 (AT2) tonically inhibits the angiotensin converting enzyme. Kid. Int., 57:570-577, 2000.

Tamura, M., Utsunomiya, H., Nakamura, M., Landon E.J.: Effect of dietary cardiac glycosides on blood pressure regulation in rats. Can. J. Physiol. Pharmacol., 78:548-556, 2000.

Tamura, M., Takagi, T., Howard, E.F., Landon, E.J., Steimle, A., Tanner, M. and Myers, P.R.: Induction of angiotensin II subtype 2 receptor-mediated blood pressure regulation in synthetic diet-fed rats. J. Hypertens., 18:1238-1246, 2000.

Takaya, J., Matsusaka, T., Katori, H., Tamura, M., Miyazaki, Y., Homma, T., Ichikawa, I.: In situ demonstration of angiotensin-dependent and independent pathways for hyperaldosteronism during chronic extracellular fluid volume depletion. Mol Endocrinol, 15: 2229-2235, 2001.

Sato, H., Tachifuji, A., Tamura, M. and Miyakawa, I. Identification of YMN-1 antigen protein and biochemical analyses of protein components involved in the mitochondrial nucleoid fraction of the yeast Sacchromyces cerevisea. Protoplasma, 219: 51-56, 2002.

Takagi, T., Nakano, Y., Takekoshi, S., Inagami, T. and Tamura, M. Hemizygous mice for the angiotensin II type 2 receptor gene have attenuated susceptibility to azoxymethane-induced colon tumorigenesis. Carcinogenesis 23, 1235-1241, 2002.

Utsunomiya, H., Nakamura, M., Kakudo, K., Inagami, T and Tamura, M.: Development of angiotensin II type 2 receptor antibody in its knockout mice: an immunohistochemical study in rat cardiovascular tissues. Regulatory Peptides 126, 155-161, 2005.

Kanehira, T., Tani, T., Nakano, Y., Takagi, T., Howard, E.F., Tamura, M. Angiotensin II type 2 receptor gene deficiency attenuates susceptibility to Tobacco-specific nitrosamine -induced lung tumorigenesis: Involvement of TGF-b-dependent cell growth attenuation. In press, Cancer Res, 2005.