Faculty

 

 

 

 

 

Chris R. Ross

DVM, University of Missouri, 1981
PhD, Physiology, University of Missouri, 1990

Phone (785) 532-4507
e-mail ross@vet.k-state.edu

Resume ( Doc | Pdf )

 

 

 

 

 

Research Interests:

My research interests lie in the interaction of the cardiovascular system with innate immune mechanisms. For example, we are currently investigating the participation of an oxidant-generating enzyme (NADPH oxidase) in inflammatory cell injury, and the degree to which injury can be limited by inhibition of the NADPH oxidase by antimicrobial peptides. Other interests include the participation of antimicrobial peptides in protection from bovine pinkeye.

Selected Publications:

Shi, J, CR Ross, MM Chengappa, MJ Sylte, DS McVey, F Blecha. Antibacterial activity of a synthetic peptide (PR-26) derived from PR-39, a proline-arginine-rich neutrophil antimicrobial peptide. Antimicrobial Agents and Chemotherapy 40(1):115-121, 1996.

Shi, J, CR Ross, TL Leto, F Blecha. PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity. Proc. Nat. Acad. Sci., USA 93: 6014-6018, 1996.

Kilgore, JL, TI Musch, CR Ross. Regional distribution of HSP70 proteins after myocardial infarction in the rat. Basic Research in Cardiology 91(4):283-288, 1996.

Huang, H-J, CR Ross, F Blecha. Chemoattractant properties of PR-39, a neutrophil antibacterial peptide. J. Leukoc. Biol. 61(5):624-629, 1997.

Zhang, G, CR Ross, S Dritz, J Nietfeld, F Blecha. Salmonella infection increases porcine antimibacterial peptide concentrations in serum. Clinical and Diagnostic Laboratory Immunology 4:774- 777, 1997.

Zhang, G, H Wu, J Shi, T Ganz, C Ross, F Blecha. Molecular cloning and tissue expression of porcine ß-defensin 1. FEBS Letters 424: 37-40, 1998.

Kilgore, JL, TI Musch, CR Ross. Physical activity and the HSP70 response. Canadian Journal of Applied Physiology 23(3):245-260, 1998.

A Al-Mehdi, G Zhao, C Dodia, K Tozawa, K Costa, V Muzykanlov, C Ross, F Blecha, M Dinauer, A Fisher. Endothelial NADPH oxidase as the source of oxidants with lung ischemia or high K+. Circulation Research 83:730-737, 1998.

Wu, H, G Zhang, C Ross, F Blecha. Ontogeny and tissue specificity of cathelicidin gene expression in porcine tissues. Infection and Immunity 67(1):439-442, 1999.

Shi, J, G Zhang, H Wu, C Ross, F Blecha, T Ganz. Porcine epithelial ß-defensin-1 is expressed in the tongue at antimicrobial concentrations. Infect Immun. 67(6):3121-7, 1999.

RJ Korthuis, D Gute, F Blecha, Ross, CR. PR-39, a proline/arginine-rich antimicrobial peptide, prevents postischemic microvascular dysfunction. Am. J. Physiol. 277 (3 Pt.2):H1007-H1013, 1999.

Zhang, G, H Hiraiwa, H Yasue, H Wu, C Ross, D Troyer, F Blecha. Characterization of the gene for porcine epithelial ß-defensin-1. Genomic structure, chromosomal localization, and constitutive expression during infection. J. Biol. Chem., 274:24031-24037, 1999.

Zhang, G, H Wu, CR Ross, JE Minton, F Blecha. Cloning of porcine NRAMP1 and its induction by lipopolysaccharide, tumor necrosis factor-a, and interleukin-1ß: Role of CD14 and mitogen-activated protein kinases. Infection and Immunity 68(3):1086-1093, 2000.

Mattson, JP, CR Ross, JL Kilgore, TI Musch. Induction of mitochondrial stress proteins following treadmill running. Medicine and Science in Sports and Exercise 32(2):365-369, 2000.

Zhang, G, C Ross, F Blecha. Porcine antimicrobial peptides: new prospects for ancient molecules of host defense. In press, Veterinary Research 31(3), 2000.

Barchowsky, A, L Klei, K Smith, CR Ross. Oxidant signaling mechanisms initiated by low levels of arsenic in vascular cells. in Metal Ions in Biology and Medicine, Vol. 6, ed. J.A. Centeno, P. Collery, G. Vernet, R.B. Finkelman, H. Gibb, J-C Etienne, John Libbey and Co., Ltd. pp. 47-49, 2000.

Wu, H G Zhang, JE Minto, CR Ross, F Blecha. Regulation of cathelicidin gene expression: Induction by lipopolysaccharide, interleukin-6, retinoic acid, and Salmonella enterica serovar infection. Infection and Immunity 68(10):5552-5558, 2000.

Akgur, F, M Brown, G Zibari, J McDonald, C Epstein, CR Ross, DN Granger. Role of superoxide in hemorrhagic shock-induced P-selectin expression. American Journal of Physiology, Heart Circ Physiol. 279(2):H791-H797, 2000.

Hoffmeyer, MR, SP Jones, CR Ross, B Sharp, MB Grisham, FS Laroux, TJ Stalker, R Scalia, DJ Lefer. Myocardial ischemia-reperfusion injuyr in NADPH oxidase-deficient mice. Circulation Research 87(9):812-817, 2000.

Hoffmeyer, MR, R Scalia, CR Ross, DJ Lefer. PR-39, a potent neutrophil inhibitor, attenuates myocardial ischemia/reperfusion injury in mice. American Journal of Physiology 279:H2824-H2828, 2000.

Ikeda, Y, LH Young, R Scalia, CR Ross, AM Lefer. PR-39, a proline/arginine-rich antimicrobial peptide, exerts cardio protective effects in myocardial ischemia/reperfusion. Cardiovascular Research, 49(1):69-77, 2001.

Stokes, Karen, E. Chris Clanton, Janice M. Russell, Chris R. Ross, and D. Neil Granger. NAD(P)H oxidase-derived superoxide mediates hypercholesterolemia-induced leukocyte-endothelial cell adhesion. Circulation Research 88(5):499-505, 2001.

Rozanov C, Roy A, Mokashi A, Daudu P, Ross C, Lahiri S. Inhibition or lack of NAD(P)H oxidase subunits do not alter the normal cytosolic calcium, sensory and respiratory response of chemoreceptors. Adv Exp Med Biol 499:67-72, 2001.

Kreiglstein, C, Wolfgang Cerwinka, James W. Salter, Janice M. Russell, Guido Shuermann, Matthew B. Grisham, Christopher R. Ross, D. Neil Granger. Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: Divergent roles of superoxide and nitric oxide. Journal of Experimental Medicine 194(9): 1207-1218, 2001.

Ramanathan, B, EG Davis, CR Ross, F Blecha. Cathelicidin antimicrobial peptides: a review. Microbes and Infect 4: 361-372, 2002.

Wu, H, CR Ross, F Blecha. Characterization of an upstream open reading frame in the 5' untranslated region of PR-39, a cathelicidin antimicrobial peptide, PR-39. Molecular Immunology, 39(1-2):9, 2002.

Madhani, M, A Barchowsky, L Klei, C Ross, S Jackson, H Swartz, P James. Anti-Bacterial peptide PR-39 affects local nitric oxide and preserves tissue oxygenation in the liver during septic shock. Accepted for publication, Biochimica et Biophysica Acta 1588(3):232, 2002.

Yamaguchi, T, C Dayton, CR Ross, T Yoshikawa, D Gute, RJ Korthuis. Late preconditioning by ethanol is initiated via an oxidant-dependent signaling pathway. Free Radical Biology and Medicine 34(3):365-76, 2003.

Cerwinka, W, D Cooper, C Krieglestein, CR Ross, J McCord, D Neil Granger. Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules. American Journal of Physiology 284:H535-541, 2003.

James, PE, M Madhani, C Ross, L Klei, A Barchowsky, H Swartz. Tissue hypoxia during bacterial sepsis is attenuated by PR-39, an anti-bacterial peptide. Adv. Exp. Biol. Med. 530:645-652, 2003.

Ramanathan, B, H Wu, CR Ross, F Blecha. Delay of apoptosis by PR-39, a porcine antimicrobial peptide: Involvement of caspase 3. Dev. Comp. Immunol. 28(2):163-169, 2004.

Ramanathan, B, JE Minton, C Ross, F Blecha. Cloning of porcine triggering receptor expressed on myeloid cells-1 (TREM-1) and its induction by lipopolysaccharide, peptidoglycan, and Salmonella enterica serovar Typhimurium infection. Dev. Comp. Immunol. 29:1-7, 2004.

Ramanathan, B, JE Minton, C Ross, F Blecha. Characterization of bovine cDNA encoding triggering receptor expressed on myeloid cells 1 (TREM-1). Veterinary Immunology and Immunopathology 102:85-89, 2004.