Faculty

David C. Poole PhD, UCLA, 1986 DSc, Liverpool John Moores University, 2000 Phone (785) 532-4529   e-mail poole@vet.k-state.edu

Research Interests:

David Poole is recognized internationally for his contributions to the fields of pulmonary gas exchange and skeletal muscle structure/function relationships. He has published over 100 peer reviewed papers in journals such as Circulation Research, Journal of Clinical Investigation, American Journal of Physiology and the Journal of Applied Physiology. Dr. Poole contributes invited chapters to major textbooks and presents his work before National and international scientific audiences on a regular basis. Since 1986, Dr. Poole has been awarded over 4 million dollars in funding and currently is examining the relationships between skeletal muscle structure and oxygen delivery at the microcirculatory level. This approach is anticipated to provide unique insights into the functional abnormalities which are associated with major disease conditions such as emphysema, diabetes and chronic heart failure.

Dr. Poole's laboratory is currently funded by grants from the National Institutes of Health and encourages a vibrant scientific atmosphere which stimulates productive interactions among faculty and students. Foremost among his collaborators at K-State, Dr. Poole wishes to acknowledge the significant contributions of Dr. Thomas J. Barstow, Dr. Timothy I. Musch, Dr. Howard H. Erickson, Dr. M. Roger Fedde, Dr. Casey A. Kindig and Dr. Brad J. Behnke.

In collaboration with Professor Andrew M. Jones of Manchester Metropolitan University in England, Dr. Poole has recently published a textbook entitled: "Oxygen Uptake Kinetics in Sport, Exercise and Medicine." This book is published by Routledge, London and New York, 2005, ISBN #-0-415-30560-8 (hardback) and 0-415-30561-6 (softback).

Selected Publications:

Musch, T.I., K.E. Eklund, K.S. Hageman, and D.C. Poole. Altered regional blood flow responses to submaximal exercise in older rats. J. Appl. Physiol. 96: 81-88, 2004.

McDonough, P., B.J. Behnke, T.I. Musch, and D.C. Poole. Recovery of microvascular PO2 during the off-transient in muscles of different fiber type. J. Appl. Physiol. 96(3):1039-44, 2004.

Poole, D.C., B.J. Behnke, P. McDonough, and D.F. Wilson. Measurement of muscle microvascular oxygen pressures: compartmentalization of phosphorescent probe. Microcirc. 11(4):317-326, 2004.

Behnke, B.J., M.D. Delp, S.A. Spier, D.C. Poole, and T.I. Musch. Effects of chronic heart failure on microvascular oxygen exchange dynamics in muscles of contrasting fiber type. Cardiovasc. Res. 6: 325-332, 2004.

Mattson, J.P., M.D. Delp, and D.C. Poole. Differential effects of emphysema on skeletal muscle fiber atrophy in hamsters. Europ. Respir. J. May;23(5):703-7, 2004.

McDonough, P., C.A. Kindig, T.S. Hildreth, D.J. Padilla, B.J. Behnke, H.H. Erickson and D.C. Poole. Effect of furosemide and the equine nasal strip on EIPH and time to fatigue in running Thoroughbred horses. Equine Comp. Exerc. Physiol. 1(3): 177-184, 2004.

Padilla, D.J., P. McDonough, C.A. Kindig, B.J. Behnke, H.H. Erickson, and D.C. Poole. Control of ventilation and arterial CO2 pressure following cessation of exercise in the Thoroughbred horse. J. Appl. Physiol. Jun;96(6):2187-93, 2004.

McDonough, P., B.J. Behnke, T.I. Musch, and D.C. Poole. Effects of chronic heart failure on recovery of microvascular PO2 in muscles of opposing fiber types. J. Exp. Physiol. 89(4):473-85, 2004.

Kano, Y., D. Padilla, K.S. Hageman, D.C. Poole, and T.I. Musch. Downhill running: A model of exercise hyperemia in the rat spinotrapezius muscle. J. Appl. Physiol. 97(3): 1138-42, 2004.

Hildreth, T.S., P. McDonough, D.J. Padilla, J.H. Cox, D.C. Poole, and H.H. Erickson. The effect of herbal supplementation on the severity of exercise-induced pulmonary hemorrhage. Equine Comp. Exerc. Physiol. In press.

Koga, S., D.C. Poole, T. Shiojiri, N. Kondo, Y. Fukuba, A. Miura, and T.J. Barstow. A comparison of oxygen uptake kinetics during knee extension and cycle exercise. Am. J. Physiol. 288(1): R212-20, 2005. Epub 2004 Aug 26.

Behnke, B.J., M.D. Delp, P.J. Dougherty, T.I. Musch and D.C. Poole. Effects of aging on microvascular oxygen pressures in rat skeletal muscle. Respir. Physiol. Neurobiol., in press.

McDonough, P., B.J. Behnke, D.J. Padilla, and T.I. Musch, and D.C. Poole. Control of microvascular oxygen pressures in muscles comprised of different fibre types. J. Physiol., in press.