Faculty

 

 

 

Butch KuKanich
Assistant Professor

PhD, Comparative Biomedical Sciences, NC State University, 2005 DVM, VA-MD Regional College of Veterinary Medicine, Virginia Tech, 1997
Diplomate, ACVCP

Phone (785) 532-4554
Email: kukanich@ksu.edu

 

 

 

 

 

Research Interests:

The focus of the Analytical Pharmacology Laboratory at Kansas State University is the evaluation and design of rational drug dosages through the use of pharmacokinetic, pharmacodynamic, and pharmacokinetic-pharmacodynamic studies. The analytical methodology currently available in the Analytical Pharmacology Laboratory includes: HPLC, LC/MS, and florescence polarization immunoassay (FPIA). The evaluation of analgesics and analgesic adjuncts in companion animals is an area of current research for the laboratory. The assessment of opioids, NMDA antagonists, adrenergic agonists, and GABA-ergic drugs compromise the bulk of the efforts. Additionally, collaborative studies in all areas of pharmacology are supported by the laboratory through analytical methodology, pharmacokinetic, and pharmacokinetic-pharmacodynamic modeling.

Selected Publications:

Bach, J.F., KuKanich, B., Papich, M., McKiernan, B.C. Evaluation of the bioavailability and pharmacokinetics of two extended-release theophylline formulations in dogs. Journal of the American Veterinary Medical Association. 2004; 224(7): 1113-1119.

KuKanich, B., Papich, M., Huff, D., Stoskopf, M. Comparison of amikacin pharmacokinetics in a killer whale (Orcinus orca) and a beluga whale (Delphinapterus leucas). Journal of Zoo and Wildlife Medicine. 2004; 35(2): 179-184.

KuKanich, B., Papich, M. Pharmacokinetics of tramadol and O-desmethyltramadol in dogs. Journal of Veterinary Pharmacology and Therapeutics. 2004; 27: 239-246.

KuKanich, B., Papich, M. Plasma profile and pharmacokinetics of dextromethorphan following intravenous and oral administration in healthy dogs. Journal of Veterinary Pharmacology and Therapeutics. 2004; 27: 337-341.

KuKanich, B., Lascelles, B.D.X., Papich, M.G. Pharmacokinetics of morphine and plasma concentrations of morphine-6-glucuronide following morphine administration to dogs. Journal of Veterinary Pharmacology and Therapeutics. 2005; 28(4). 371-376.

KuKanich, B., Lascelles, B.D.X., Papich, M.G. Validation of a high-pressure liquid chromatography and fluorescence polarization immunoassay for the determination of methadone in canine plasma. Therapeutic Drug Monitoring. 2005; 27(3): 389-392.

KuKanich, B., Lascelles, B.D.X., Papich, M.G. Evaluation of a von Frey Device for pharmacodynamic modeling of morphine in dogs. (in press, American Journal of Veterinary Research).

KuKanich, B., Lascelles, B.D.X., Papich, M.G. Pharmacokinetics and pharmacodynamics of morphine in dogs following intravenous infusion and multiple intravenous doses. (in press, American Journal of Veterinary Research)

KuKanich, B., Gehring, R., Webb, A.I., Craigmill, A.L., Riviere, J.E. FARAD Digest: Effect of formulation and route of administration on tissue residues and withdrawal times. (in press, Journal of the American Veterinary Medical Association)

KuKanich, B., Lascelles, B.D.X., Papich, M.G. Inhibition of cytochrome P450 3A, P-glycoprotein, and gastric acid secretion do not alter oral bioavailability of methadone in dogs. (in press, Journal of Veterinary Pharmacology and Therapeutics)